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Multiplex detection of 14 fentanyl analogues and U-47700 in biological samples: Application to a panel of French hospitalized patients

Research Organization: University of Lorrain
Organizational Sponsorship:
Principal Investigator: Jean Jung
Email Address: JJung@nullgmail.com
Discipline: test
Abstract:

Synthetic opioids (SO) associated with the recent alarming increase of deaths and intoxications in United States of America and Europe are not detected by the usual first-line opiates drug screening assays. We developed a liquid chromatography tandem mass spectrometry analytical method for the multiplex detection of 14 fentanyl analogues (2-furanylfentanyl, 4-ANPP, 4-methoxybutyrylfentanyl, acrylfentanyl, alfentanil, carfentanil, despropionyl-2-fluorofentanyl, fentanyl, methoxyacetylfentanyl, norfentanyl, ocfentanil, remifentanil, sufentanil and valerylfentanyl) and U-47700 in whole blood and urine samples. The method was validated according to the requirements of ISO 15189. A simple and fast liquid-liquid extraction (LLE) with De-Tox Tube-A was performed leading to better recovery of molecules in urine than in blood samples

Publication URL: https://www.sciencedirect.com/science/article/pii/S0379073820302991#!
Final Report:


Testing the new form2

Research Organization: Testing the new form2
Organizational Sponsorship: Testing the new form2
Principal Investigator: Testing the new form2
Email Address: testing2@nulltesting.com
Discipline: Biology/Serology
Abstract:

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Publication URL: http://testing.com
Final Report: Testing-the-new-form.pdf